Table 3.
Cox univariate and multivariate analyses of the 142 patients with S-PM CRC
| Variable | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Sex (female) | 1.29 (0.83–2.02) | 0.250 | ||
| CEA (≥5.0 ng/mL) | 1.91 (1.18–3.09) | 0.008 | 1.66 (1.01–2.73) | 0.040 |
| CA199 (≥37.0 U/mL) | 1.82 (1.17–2.86) | 0.008 | 1.19 (0.74–1.91) | 0.450 |
| CA125 (≥35.0 U/mL) | 1.22 (0.88–1.62) | 0.350 | ||
| Location | ||||
| Right-sided colon | Reference | 0.570 | ||
| Left-sided colon | 0.51 (0.31–0.83) | |||
| Rectum | 0.83 (0.44–1.58) | |||
| Obstruction | 1.43 (0.89–2.29) | 0.130 | ||
| CRS (CC-2) | 3.49 (2.02–6.01) | <0.001 | 2.81 (1.59–4.99) | <0.001 |
| HIPEC (Yes) | 0.46 (0.29–0.73) | 0.001 | 0.53 (0.32–0.86) | 0.010 |
| KRAS (mut) | 1.06 (0.68–1.65) | 0.790 | – | |
| BRAF (mut) | 4.32 (2.72–6.85) | <0.001 | 4.35 (2.69–7.01) | <0.001 |
| Category (T4) | 1.52 (0.97–2.38) | 0.060 | ||
| Category (N1–2) | 1.14 (0.82–1.59) | 0.420 | ||
| Histology (mucinous adenocarcinoma and signet ring cell carcinoma) | 1.53 (0.92–2.53) | 0.090 | ||
| PCI (≥20) | 1.21 (0.62–2.35) | 0.600 | ||
CRC = colorectal cancer, S-PM = synchronous peritoneal metastasis, CRS = cytoreductive surgery, HIPEC = hyperthermic intraperitoneal chemotherapy, mutKRAS/wtKRAS = KRAS mutation/KRAS wild-type, mutBRAF/wtBRAF = BRAF mutation/BRAF wild-type.