Table 3.
SMS2 modified animal models in various mouse studies.
| Reference | Animal model | Study | Generated |
|---|---|---|---|
| Honma et al. (67) | SMS2 knock out (KO) mice | Skin study | Generated by homologous recombination using targeted vectors |
| Chiang et al. (68) | Hepatocyte-specific Sms1 KO/global Sms2/global Smsr triple KO mice | Liver study | Hepatocyte-specific Sms1/global Sms2 double KO mice (Li et al. (69)) and global Smsr KO mice (Ding et al. (70)) |
| Ou et al. (71) | SMS2 KO and 3H9/Sgms2 KO mice | Lupus erythematosus study | SMS2 KO (Liu et al. (72)) 3H9 knockin mice (Chen et al. (73)) |
| Chiang et al. (74) | Hepatocyte-specific Sms1 KO/global Sms2/global Smsr triple KO mice | Liver study | Hepatocyte-specific Sms1/global Sms2 double KO mice (Li et al. (69)) and global Smsr KO mice (Ding et al. (70)) |
| Sakai et al. (75) | SMS2 KO mice | Epidermis study | Mitsutake et al. (65) |
| Li et al. (69) | Hepatocyte-specific Sms1/global Sms2 double KO mice | Liver study | Sms2 KO mice (Liu et al. (72)) |
| Sugimoto et al. (76) | SMS2 KO mice | Liver study | Mitsutake et al. (65) |
| Deng et al. (77) | SMS2 KO mice | Cancer study | Liu et al. (72) |
| Taniquchi et al. (78) | SMS2 KO + SMS2 KO mice, which have a floxed allele for SMS1 (SMS2-/-;SMS1f/f) | Cancer study | SMS2 KO (Mitsutake et al. (65)) and SMS2−/− mice with a SMS1 fl/fl (Ohnishi et al. (79)) |
| Matsumoto et al. (16) | Sp7-Cre;SMS1f/f;SMS2−/− and ERT2-Cre;SMS1 f/f;SMS2−/− mice generated from SMS2−/−;SMS1f/f mice | Analyzed the phenotype of a conditional knockout mouse; Sp7-Cre;SMS1f/f;SMS2-/- mouse | SMS2−/− mice with a SMS1 fl/fl (Ohnishi et al. (79)) |
| Xue et al. (80) | SMS2 KO mice | Cerebral ischemia study | Hailemariam et al. (66) |
| Gupta et al. (81) | SMS2 KO mice | Pulmonary function study | Liu et al. (72) |
| Nomoto et al. (82) | SMS2 KO mice | Skin study | Mitsutake et al. (65) |
| Ohnishi et al. (79) | SMS2-/-;SMS1f/f generated from SMS2 KO mice | Dextran sodium sulfate (DSS)–induced murine colitis study | SMS2 KO mice (Mitsutake et al. (65)) |
| Wang et al. (83) | SMS2 KO mice | Learning ability study | Mitsutake et al. (65) |
| Sakamoto et al. (84) | SMS2 KO mice | Study on SMS2 function and properties | Mitsutake et al. (65) |
| Sugimoto et al. (85) | SMS2 KO mice + loxP-floxed SMS2 mice | Study on insulin-targeted tissues | SMS2 KO mice (Mitsutake et al. (65)) |
| Sugimoto et al. (86) | SMS2 KO mice | Liver and kidney study | Mitsutake et al. (65) |
| Wang et al. (87) | SMS2 KO mice | Study on alcohol-induced neuroapoptosis | Liu et al. (72) |
| Ding et al. (70) | Smsr/Sms2 double KO | Study on SMSr function | SMS2 KO (Liu et al. (72)) |
| Li et al. (88) | SMS2 liver-specific transgenic and SMS2 KO mice | Hepatic steatosis study | Produced in their lab |
| Lu et al. (89) | SMS2 KO | Study on auditory function | Mitsutake et al. (65) |
| Subbaiah et al. (90) | SMS2 KO mice | Cholesterol study | Hailemariam et al. (66) |
| Deng et al. (91) | SMS2 KO mice | Study on neurons | N/A, article not in English |
| Li et al. (92) | Sms2 KO mice | Insulin study | Hailemariam et al. (66), Liu et al. (72) |
| Mitsutake et al. (65) | SMS2 KO mice | Study on the physiological function of SMS2 | Deletion of the SMS2-exon 2, with a cassette encoding β-galactosidase and a neomycin-selectable marker, homologues recombination |
| Zhang et al. (93) | SMS2 KO mice | Brain study | Hailemariam et al. (66) |
| Gowda et al. (94) | SMS2 KO mice | Lung study | Hailemariam et al. (66) |
| Fan et al. (95) | SMS2/Apoe double KO mice | Atherosclerosis study | Produced in their lab |
| Qin et al. (96) | SMS2 KO mice | Atherosclerosis study | N/A, article not in English |
| Liu et al. (72) | SMS2 KO mice | Atherosclerosis study | Hailemariam et al. (66) |
| Hailemariam et al. (66) | SMS2 KO mice | NFκB activation study | Replaced 90% of SMS2-exon 2, with the neomycin-resistant gene, homologous recombination |