TABLE 2.
PAEs, SMEs, and PA-SMEs of quinupristin-dalfopristin for staphylococcia
| Strain (drug susceptibility)b | Mean (range) effect (h)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| PAEc | 0.1 × MIC
|
0.2 × MIC
|
0.3 × MIC
|
0.4 × MIC
|
|||||
| SME | PA-SME | SME | PA-SME | SME | PA-SME | SME | PA-SME | ||
| S. aureus (Metr Erys) | 5.9 (5.4–6.1) | 0 (0–0.2) | 6.9 (6.6–7.1) | 0.1 (0–0.3) | 8.0 (7.8–8.2) | 0.4 (0.3–0.6) | 8.8 (8.6–9.0) | 0.6 (0.5–0.7) | 10.4 (10.1–10.6) |
| S. aureus (Metr Erys) | 7.0 (6.7–7.3) | 0 (0–0.1) | 8.1 (7.9–8.3) | 0.4 (0.1–0.8) | 9.2 (8.9–9.5) | 0.7 (0.4–0.9) | 10.7 (10.4–11.1) | 1.1 (0.8–1.2) | 11.2 (10.1–12.7) |
| S. aureus (Metr Erys) | 4.6 (4.1–5.1) | 0 | 5.6 (5.0–6.0) | 0 | 7.5 (6.7–8.7) | 0.2 (0–0.4) | 8.0 (7.6–8.5) | 0.7 (0.5–1.5) | 9.4 (9.2–9.5) |
| S. aureus (Metr inducibly Macr) | 5.7 (5.2–6.3) | 0 | 6.4 (5.5–6.8) | 0.2 (0.1–0.3) | 7.3 (6.6–7.9) | 1.0 (0.8–1.3) | 8.6 (7.7–9.3) | 1.3 (1.2–1.6) | 10.4 (8.8–11.6) |
| S. aureus (Metr inducibly Macr) | 5.5 (5.1–5.8) | 0.1 (0–0.2) | 6.5 (6.0–7.1) | 0.8 (0.3–0.9) | 7.7 (7.2–8.4) | 1.2 (1.1–1.4) | 8.9 (8.5–9.8) | 1.5 (1.2–1.8) | 10.9 (9.8–12.9) |
| S. aureus (Metr constitutively Macr) | 2.3 (1.9–2.7) | 0.4 (0.3–0.6) | 3.3 (3.1–3.5) | 1.1 (0.9–1.4) | 4.8 (4.2–5.2) | 2.5 (1.6–3.2) | 7.1 (6.6–7.5) | 7.8 (6.3–9.0) | 9.7 (8.5–10.7) |
| S. aureus (Metr constitutively Macr) | 2.5 (2.2–2.9) | 0 | 3.8 (3.2–4.3) | 0.8 (0.2–1.4) | 5.5 (3.9–7.3) | 3.1 (2.4–3.5) | 6.6 (5.4–8.8) | 7.3 (6.4–8.2) | 10.4 (9.3–12.5) |
| Coagulase-negative staphylococci (Mets) | 4.7 (4.2–5.3) | 0.3 (0.1–0.5) | 4.9 (4.6–5.4) | 0.4 (0.2–0.6) | 5.3 (4.9–6.0) | 0.4 (0.2–0.6) | 5.6 (5.3–6.0) | 0.8 (0.5–1.2) | 6.6 (6.5–6.9) |
| Coagulase-negative staphylococci (Mets) | 5.3 (4.6–5.8) | 0.3 (0.1–0.4) | 5.7 (4.8–6.3) | 0.2 (0–0.4) | 6.0 (4.6–6.9) | 0.3 (0–0.6) | 6.5 (5.4–7.1) | 0.8 (0.3–1.2) | 6.7 (6.0–7.1) |
| Coagulase-negative staphylococci (Metr) | 4.0 (2.7–5.8) | 0 | 4.0 (2.9–5.3) | 0.1 (0–0.3) | 4.6 (3.0–6.0) | 0.3 (0–0.7) | 4.6 (3.4–6.0) | 0.3 (0–0.7) | 5.9 (5.1–7.3) |
| Coagulase-negative staphylococci (Metr) | 4.0 (3.6–4.4) | 0 | 4.1 (3.5–4.5) | 0.1 (0–0.4) | 4.9 (4.1–5.6) | 0.7 (0.4–1.3) | 5.1 (4.4–5.6) | 0.4 (0–0.6) | 6.4 (5.9–7.3) |
a
See Table 1, footnote a.
b
Met, methicillin; Ery, erythromycin; Mac, macrolide; s, susceptible; r, resistant.
c
Initial exposure concentration, 10 times the MIC.