TABLE 3.
PAEs, SMEs, and PA-SMEs of quinupristin-dalfopristin for vancomycin-susceptible and -resistant E. faecium strains
| Phenotypea | Exposure concn (× MIC) | Mean (range) effect (h)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PAE | 0.1 × MIC
|
0.2 × MIC
|
0.3 × MIC
|
0.4 × MIC
|
||||||
| SME | PA-SME | SME | PA-SME | SME | PA-SME | SME | PA-SME | |||
| Vans | 10 | 8.6 (8.3–8.9) | 0.3 (0–0.5) | 11.2 (10.3–12.5) | 0.3 (0–0.6) | >12 | 1.0 (0.7–1.5) | >12 | 3.6 (2.0–4.4) | >12 |
| 0.25 | 8.4 (8.1–9.0) | 0 | 8.5 (8.1–9.2) | 0 | 9.3 (9.0–9.5) | 0 | 9.8 (9.5–10.2) | 0.3 (0–0.5) | 10.7 (10.3–11.2) | |
| Vans | 10 | 8.4 (7.7–8.8) | 0.4 (0.3–0.5) | 11.8 (11.3–12.5) | 0.6 (0.5–0.7) | >12 | 2.1 (1.5–2.7) | >12 | 9.0 (8.3–9.5) | >12 |
| 0.25 | 8.6 (8.0–9.5) | 0.2 (0–0.6) | 8.9 (8.2–9.7) | 0 (0–0.1) | 9.5 (9.0–9.9) | 0 (0–0.1) | 9.6 (9.1–10.4) | 0.1 (0–0.2) | 10.9 (10.7–11.4) | |
| Vanr | 2.5 (2.0–2.8) | 0.1 (0–0.4) | 2.8 (2.1–3.5) | 0.4 (0.1–0.7) | 3.4 (3.0–3.8) | 1.0 (0.6–1.2) | 4.5 (4.1–5.2) | 3.1 (2.5–3.8) | 5.6 (4.6–6.5) | |
| Vanr | 2.7 (2.4–3.1) | 0.9 (0.3–2.0) | 3.4 (3.0–3.7) | 1.0 (0.3–1.7) | 4.3 (3.8–4.8) | 2.4 (1.7–3.5) | 5.4 (4.6–6.2) | 4.3 (3.7–4.8) | 7.1 (6.3–8.7) | |
a
Vanr, vancomycin resistant; Vans, vancomycin susceptible.