Table 3.
Associations between DRD2, COMT and DRD4 polymorphisms and antipsychotic treatment response under five genetic models by using chi-square and logistic regression for the AORs
| Gene polymorphism (W>M) | Heterozygous model WW vs WM |
Heterozygous model WW vs WM |
Recessive model WW + WM vs MM |
Dominant model WW vs WM + MM |
Codominant model WW + MM vs WM |
|---|---|---|---|---|---|
|
P value OR(95%CI) A P value AOR†(95%CI) |
P value OR(95%CI) A P value AOR†(95%CI) |
P value OR(95%CI) A P value AOR†(95%CI) |
P value OR(95%CI) A P value AOR†(95%CI) |
P value OR(95%CI) A P value AOR†(95%CI) |
|
|
DRD2 A-241G rs1799978 (A > G) |
0.214 | 0.108 | 0.243 | 0.061 | 0.128 |
| - | 2.712(0.775–9.483) | - | 3.314(0.978–11.232) | 2.579(0.739–9.003) | |
| 1.000 | 0.154 | 1.000 | 0.137 | 0.155 | |
| - | 4.113(0.588–28.780) | - | 4.296(0.630-29.275) | 4.115(0.586–28.87) | |
|
COMT rs4680 (G > A) (Val > Met) |
0.366 | 0.228 | 0.636 | 0.195 | 0.352 |
| 0.60(0.041–2.753) | 0.587(0.246–1.399) | 0.781(0.280–2.175) | 0.591(0.266–1.313) | 0.685(0.308–1.522) | |
| 0.563 | 0.392 | 0.498 | 0.605 | 0.295 | |
| 1.7160(0.275-10.693) | 0.552(0.142–2.147) | 1.727(0.356–8.383) | 0.725(0.215–2.446) | 0.509(0.143–1.804) | |
|
DRD4 120bp duplication (240bp > 120 bp) |
0.055 | 0.053 | 0.295 | 0.033* | 0.273 |
| 0.282(0.076–1.052) | 0.385(0.144–1.028) | 0.559(0.280–2.175) | 0.361(0.139–0.938) | 0.640(0.288–1.424) | |
| 0.994 | 0.074 | 0.308 | 0.043* | 0.244 | |
| 0.001>(0.001> -_) | 0.243(0.052–1.148) | 0.334(0.041–2.753) | 0.196(0.041–0.949) | 0.461(0.126–1.695) |
Abbreviations: OR: odds ratio, AOR: adjusted odds ratio, COMT: catechol-O-methyltransferase; DRD2: dopamine receptor D2; DRD4: dopamine receptor D4, W: wild allele (more frequent allele), M: mutant allele(less frequent allele). A P value: adjusted P value. Notes: *: statistical significance, †: AOR for sex, age, marital status, age of disease onset and duration of hospitalization