Table 4.
Gene-gene Interaction analysis for 2 and 3 locus models by using logistic regression
| polymorphism1 | polymorphism2 | OR (95%CI) | P value | Genotype combination |
Respond-ers
(N = 51) † |
Resist-ants
(N = 50) ‡ |
|
|---|---|---|---|---|---|---|---|
|
DRD4 120-bp duplication 240/240 |
COMT rs4680 Val/Val |
3.232(1.056–9.892) | 0.040 |
240/240 and Val/Val |
5 | 13 | |
|
DRD2 A-241G AA |
COMT rs4680 Val/Met-Met/Met |
2.540(1.138–5.668) | 0.023 |
AA and Val/Met-Met/Met |
30 | 18 | |
|
DRD2 A-241G AA |
DRD4 120-bp duplication 120/240 − 120/120 |
3.000(1.279–7.035) | 0.012 |
AA And 120/240 − 120/120 |
38 | 26 | |
| polymorphism1 | SNP2 | SNP3 | OR (95%CI) | P value | Genotype combination |
Respond-ers (N = 51) a |
Resist-ants (N = 50) b |
|
DRD4 120-bp duplication 120/240 − 120/120 |
DRD2 A241G AA |
COMT rs4680 Val/Met-Met/Met |
2.363(1.057–5.281) | 0.036 | AA and 120/240 − 120/120 and Val/Met-Met/Met | 28 | 17 |
Notes: †: treatment responder group, ‡: treatment resistant group