FIGURE 4.

SIN1 interactome. Since the discovery of SIN1 as a subunit of mTORC2, its involvement in the assembly, the specificity of the substrate or the localization of the complex are increasingly studied. These multiple interactions in the complex and outside determine these functions in immunity, metabolism, cell growth. We have represented SIN1 and the various interactions described to date, either as direct (green line) or indirect (black line). When this interaction leads to an inhibition, we represented it in red (rectangle or line). This illustrates the growing interest in targeting mTORC2 via SIN1.