TABLE 2.

Partners of SIN1 and the interaction effect outside of mTORC2 complex proteins.

Partner	Interaction effect	References
AKT Thr450	Regulates the stability of AKT	39
AURKA	Inhibits ubiquitination and subsequent degradation of SIN1	40
BRCA1	Interacts with SIN1, RICTOR, PRR5 leading to inhibition of mTORC2 activity	41
DNA‐PK	Interact with SIN1 to activate AKT(S473)	42 , 43 , 44
IFNAR2 /IFNGR1	Interacts with respectively ovin and human SIN1 to activates IFN α,β (IFNAR2) and γ (IFNGR1) transduction pathways	45
JNK	Inhibits basal JNK activity and UV‐induced activation	34
MAPK14/p38 ATF2	Increases ATF2‐dependent transcription	36
MAP3K2, MEKK2	Negatively regulates MEKK2 activation	35
PCBP2	Enables selective expression of cell survival factors	38
RAP1	Regulates its activation and actin remodeling	37
RAS	Activates the proliferative cell cycle transcription program of RAS. Inhibits ERK activation.	29 , 46 , 47
RB	Interacts with SIN1 to inhibit mTORC2 activity	48
Sty1/Spc1	Regulates stress‐dependent transcription	49
YAP1	mTORC2 interacts with YAP via sin1, and positively regulates its transcriptional activity	50