Table 1.

Randomized trials of early progression of enteral feeding¹

Study	Year Study Population	Average GA	Initiation/Progression of Feeding
Ostertag et al,89	1986 38 infants with BW < 1500 g	28 wk (range: 26–32)	Initiation and progression on day 1 vs. day 7
Khayata et al,88	1987 12 infants with BW < 1500 g		Initiation and progression on day 2 vs. day 5
Davey et al,85	1994 62 infants with BW < 2000 g in stable condition	28.5 ± 3 wk	Initiation and progression on day 2 vs. day 5
Karagianni et al,87	2010 125 infants with GA 27–34 wk and BW < 10th percentile	31 wk (IQR: 27–34)	Initiation and progression on day 2 vs. day 7
Perez et al,90	2011 239 stable infants with GA 27–32 wk and BW < 1500 g	30 ± 2 wk	Initiation and progression on day 2 vs. day 5
Leaf et al,55	2012 404 infants with GA <35 wk and BW < 10th percentile	31 ± 2 wk	Initiation and progression on day 2 vs. day 5
Abdelmaaboud et al,81	2012 125 infants with GA <37 weeks and BW < 10th percentile	34 ± 3 wk	Initiation and progression on day 3 vs. day 6
Armanian et al,82	2013 82 infants with BW < 1500 g	30.5 ± 2 wk	Progression on day 4 vs. day 10
Arnon et al,83	2013 60 infants with GA <37 weeks and BW < 10th percentile	32 wk (IQR: 29–34)	Early initiation (<24 h) vs. late initiation
Dinerstein et al,86	2013 62 infants with BW < 1500 g	32 wk (IQR: 29–34)	Progression on day 2 vs. day 5
Srinivasan et al,91	2017 32 infants with GA < 37 wk and SGA	32 wk (SD: 2)	Progression on day 2 vs. day 5
Salas et al,56	2018 60 infants with GA <28 wk	26 wk (IQR: 24–28)	Early initiation (<72 h), progression on day 2 vs. day 5
Tewari et al,92	2018 62 infants with GA 27–32 wk and SGA	30 wk (range: 27–32)	Progression on day 1–2 vs. day 5–6
Bozkurt et al,84	2020 219 infants with BW < 1251 g	27 wk (range: 29–34)	Progression on day 2 vs. day 6

¹Abbreviations: BW, birthweight; GA, gestational age; IQR, interquartile range; SGA, small for gestational age.