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. Author manuscript; available in PMC: 2023 Oct 25.
Published in final edited form as: J Pain. 2023 Mar 1;24(7):1262–1274. doi: 10.1016/j.jpain.2023.02.024

Figure 4.

Figure 4.

Mechanical thresholds for males (A,C,E,G) and females (B,D,F,H) across the withdrawal period during week 1 (A,B), week 2 (C,D), week 3 (E,F) and week 4 (G,H). Male mechanical sensitivity begins after one week of treatment of CIEV and becomes maximal after four weeks while the females first experience mechanical sensitivity after the third week of CIEV treatment. All data are presented at mean ± SEM. N = 8 per EtOH exposed group, and 16 per AC group. * P < .05 CIEV + Pyrazole compared to AC; ** P < .01 CIEV + Pyrazole compared to AC; *** P < .001 CIEV + Pyrazole compared to AC.