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. Author manuscript; available in PMC: 2023 Oct 25.
Published in final edited form as: J Pain. 2023 Mar 1;24(7):1262–1274. doi: 10.1016/j.jpain.2023.02.024

Figure 5.

Figure 5.

Heat response latencies for males (A,C,E,G) and females (B,D,F,H) across the withdrawal period during week 1 (A,B), week 2 (C,D), week 3 (E,F) and week 4 (G, H). Female heat sensitivity begins after 1 week of treatment of CIEV and becomes maximal after four weeks while the males do not develop heat sensitivity after CIEV treatment. All data are presented at mean ± SEM. N = 8 per EtOH exposed group, and 16 per AC group. * P < .05 CIEV + Pyrazole compared to AC; **P < .01 CIEV + Pyrazole compared to AC. #P < .05 CIEV + Pyrazole compared to CIEV + Saline; ###P < .001 CIEV + Pyrazole compared to CIEV + Saline.