Skip to main content
. 2023 Oct 25;18(10):e0290653. doi: 10.1371/journal.pone.0290653

Table 1. Characteristics of the included studies.

Author (year) Study design Setting and Sample Intervention Comparator Outcome Measures
Randomised controlled trials
Alampay et al. (2020)
Pilot RCT
Setting: School-based, Philippines
Participants: n = 186
Age: 9–16 (M: 11.88; SD: 1.84)
Gender: 77 males (41.4%) and 109 females (58.6%)
Diagnosis: Experience of some degree of behavioural problem, symptoms of emotional difficulties and/or peer problems (determined using SDQ)
Mindfulness-based cognitive therapy (MBCT) adapted to Kamalyan Curriculum
Duration: 8 weekly sessions (75 minutes for younger participants, 90 minutes for older participants)
Delivery: Group format; delivered by school guidance counsellors and teachers
n = 87 (17 lost to follow-up)
Handicrafts (Craft based therapy)
Duration: 8 weekly sessions (75 minutes for younger participants, 90 minutes for older participants)
Delivery: Group format; delivered by facilitators from a women’s organisation that supports livelihood activities
n = 99 (23 lost to follow-up)
Depression Measures:
SMFQ
Anxiety Measures:
STAIC
Timings:
End of treatment
8-weeks post-treatment
Bernal et al. (2019)
RCT
Setting: Clinic-based, Puerto Rico
Participants: n = 121
Age: 13–17.5 (M, SD: NR)
Gender: 56 males (46.3%) and 65 females (53.7%)
Diagnosis: CDI score ≥20, CDRS-R ≥40, met full DSM-IV criteria for MDD, maintained clinically significant depressive symptoms for at least 6 weeks before randomisation
Name: Culturally adapted Cognitive Behavioural Therapy and parent psychoeducation intervention (TEPSI)
Duration:
CBT: 12 sessions
TEPSI: 8 2-hour sessions
Delivery:
CBT: delivered individually by Clinical Psychology graduate students
TEPSI: delivered in a group format by 2 licensed Clinical Psychologists
n = 60 (n = 13 lost to follow-up)
Culturally adapted Cognitive Behavioural Therapy
Duration: 12 sessions
Delivery: delivered individually by Clinical Psychology graduate students
n = 61 (n = 14 lost to follow-up)
Depression Measures:
CDI
CDRS-R
SIQ-Jr
DISC-IV
BDI-R
Anxiety Measures:
N/A
Timings:
Weeks 3, 5, 7, 9 of treatment
End of treatment
3-months post-treatment
6-months post-treatment
9-months post-treatment
12-months post-treatment
Damra, Nassar & Ghabri (2014)
Feasibility RCT
Setting: Clinic-based, Jordan
Participants: n = 18
Age: 10–12 (M = 11.3; SD:NR)
Gender: All-male sample
Diagnosis: Suffering from physical abuse and clinical symptoms of PTSD and depression for at least five weeks prior to treatment
Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) adapted for the Jordanian culture
Duration: 10 60-minute sessions delivered over 2 weeks
Delivery: Group-format delivered by two accredited children’s counsellors
n = 9 (0 lost to follow-up)
Wait-list control
n = 9
Depression Measures:
CDI
Anxiety Measures:
N/A
Timings:
End of treatment
4-months post-treatment
Ishikawa et al. (2019)
RCT
Setting: Clinic-based, Japan
Participants: n = 51
Age: 8–15 (M = 10.90; SD = 2.00)
Gender: 22 males (43.1%), 29 females (56.9%)
Diagnosis: Experiencing an anxiety disorder as determined using the ADIS
The Japanese Anxiety children/Adolescents Cognitive Behavioural Therapy (JACA-CBT)
Duration: 8 1-hour weekly sessions (with an optional 3 booster sessions)
Delivery: Face-to face delivered by 2 clinical psychologists
n = 26
Wait-list control
n = 25
Depression Measures:
CDI
DSRS
Anxiety Measures:
ADIS
SCAS-C/SCAS-P
Timings:
Pre-treatment
End of treatment
3-months post-treatment
6-months post-treatment
Khan, Malik, Ahmed & Riaz (2020) Feasibility RCT Setting: Orphanage, Pakistan
Participants: n = 24
Age: 8–13 (M, SD: NR)
Gender: All males
Diagnosis: >30 on SCARED, not currently taking any medication nor receiving psychotherapy
Coping Cat (CC) Cognitive Behavioural Therapy adapted into Urdu
Duration: 12 40–60 minute sessions delivered weekly
Delivery: Face-to-face delivered by post-graduate clinical psychologist
n = 12
Wait-list control
n = 12 (9 lost to follow-up)
Depression Measures:
N/A
Anxiety Measures:
SCARED
CASI
Timings:
1-week pre treatment
Post-session 3
End of treatment
6-months post-treatment
Li et al. (2022)
Pilot RCT
Setting: Two primary schools, China
Participants: n = 87
Age: 8–12 (M = 11, SD = .75)
Gender: 54 male (62%), 33 female (38%)
Diagnosis: Experience of at least one traumatic event and meets DSM–5 PTSD criterion for PTSD or partial PTSD using PCL-5 checklist
Adapted version of Cohen’s trauma-focused cognitive behavioural therapy (TF-CBT)
Duration: 10-sessions, each lasting up to 50 minutes
Delivery: Face-to-face; 7 group sessions and 3 individual sessions, delivered by members of the protocol developer’s team (counsellors) from Beijing Normal University who held master’s degrees in social work
n = 45
Treatment as usual at school site—usually including emotional catharsis techniques
Duration: number of sessions decided by young person and school psychologist, each session lasting c. 45 minutes
Delivery: School psychologists
n = 42
Depression Measures:
CDI-S
Anxiety Measures:
CSAS-C
Timings:
Baseline
2-weeks post-treatment
3-months post-treatment
Listug-Lunde et al. (2013)
Pilot RCT
Setting: One rural northern plains tribal school, USA
Participants: n = 19
Age: 11–14 (CWD-A group: 11–14 years, M = 12.38, SD = .92, TAU group: 12–14 years, M = 12.5, SD = 1.07)
Gender: 10 males (62.5%), 6 females (37.5%) (remaining 3 unknown)
Diagnosis: Moderate levels of depression defined by raw scores of 15 or higher on the CDI
Skills Development Class (culturally adapted Coping with Depression Course for Adolescents: CWD-A)
Duration: 13 35 to 40-minute sessions, bi-weekly for 7 weeks followed by 2 booster sessions held within 1-month post-intervention
Delivery: Group-format delivered by two therapists: One Indian Health Services mental health professional and one graduate student
n = 10 (2 lost to follow-up)
Treatment as usual
Duration: NR
Delivery: delivered by two therapists: One Indian Health Services mental health professional and one graduate student
n = 9 (1 lost to follow-up)
Depression Measures:
CDI
Anxiety Measures
MASC
Timings:
Pre-treatment
Post-treatment
3-months post-treatment
Ramdhonee-Dowlott al. (2021)
RCT
Setting: 6 residential care institutions (RSI), Mauritius
Participants: n = 100
Age: 9–14 (M = 11.75, SD = 1.97)
Gender: 24 males (24%), 76 females (76%)
Diagnosis: RCI report on
child/adolescent displaying difficulties in managing emotions or emotional distress, no clinical cut-off but all scored above 5 on the Emotional Symptoms subscale of the self-report SDQ
Super Skills for Life (SSL) manualised CBT translated into French and adapted for Mauritian culture and use in RCI settings
Duration: 8 weekly sessions of c.45 minutes
Delivery: Face-to-face group format, delivered by developmental psychologist with 5 years of experience, assisted by one staff member at each host RCI
n = 50
Wait-list control
n = 50
Depression and Anxiety Measures:
RCADS
Video speech tasks
Timings:
1-week pre-treatment
1-week post-treatment
3-months post-treatment
Rosselló & Bernal (1999)
RCT (3 arm)
Setting: School-based, Puerto Rico
Participants: n = 71
Age: 13–11 (M: 14.10; SD: 1.40)
Gender: 33 males (46%) and 38 Females (54%)
Diagnosis: Scoring over 11 on the CDI and who met DSM-Il criteria for depression on the DISC-2 (parent or adolescent versions)
Cognitive Behavioural Therapy adapted for Puerto-Rican youth
Duration: 12 sessions delivered weekly
Delivery: Face-to-face, individual delivery by advanced graduate clinical psychology students
n = 25
Interpersonal Therapy (IPT) adapted for Puerto-Rican youth
Duration: 12 sessions delivered weekly
Delivery: Face-to-face individual delivery by advanced graduate clinical psychology students
n = 23
Wait-list control
n = 23
Depression Measures:
CDI
Anxiety Measures:
N/A
Timings:
Pre-treatment
End of treatment
3-months post-treatment
Rosselló, Bernal & Rivera-Medina (2008)
RCT (4 arms)
Setting: Schools, Puerto Rico
Participants: n = 112
Age: 12–18 (M: 14.52; SD: 1.85).
Gender: 50 males (44.6%) and 62 Females (55.4%)
Diagnosis: Scoring over 11 on the CDI and who met DSM-Il criteria for depression on the DISC-2 (parent or adolescent versions)
Individual Cognitive Behavioural Therapy
Duration: 12 sessions delivered weekly
Delivery: Face-to-face individual delivery by advanced graduate clinical psychology students
n = 23
Individual Interpersonal Psychotherapy
Duration: 12 sessions delivered weekly
Delivery: Face-to-face individual delivery by advanced graduate clinical psychology students
n = 31
Group Cognitive Behavioural Therapy
Duration: 12 sessions delivered weekly
Delivery: Face-to-face group-format by advanced graduate clinical psychology students
n = 29
Group Interpersonal Psychotherapy
Duration: 12 sessions delivered weekly
Delivery: Face-to-face individual delivery by advanced graduate clinical psychology students
n = 29
Depression Measures:
CDI
Anxiety Measures:
N/A
Timings:
Pre-treatment
End of treatment
3-months post-treatment
Saw, Tam & Bonn (2019) Pilot RCT Setting: School, Malaysia
Participants: n = 20
Age: 16 (M, SD: NR)
Gender: 10 males (50%) and 10 females (50%)
Diagnosis: raw score above the cut-off point of 76 on RADS-2
Group Cognitive Behavioural Therapy
Duration: 8 ninety-minute sessions delivered weekly
Delivery: Group format, delivered by trained local school counsellors
n = 10
Wait-list control
n = 10
Depression Measures:
RADS-2
ATQ-Malay
Anxiety Measures:
N/A
Timings:
Pre-treatment
Mid-treatment (after session 4)
Post-treatment (after session 8)
1-month post-intervention
Non-randomised trials (single treatment arm)
Acarturk et al. (2019)
Pilot study
Setting: University-based, Turkey
Participants: n = 13
Age: 13–17 (M: 14.9, SD: NR)
Gender: 4 males (30.8%), 9 females (69.2%)
Diagnosis: Diagnosis of anxiety or mood disorder based on K-SADS-PL despite taking a maximally tolerated SSRI for at least 12 weeks
Culturally Adapted Transdiagnostic Cognitive Behavioural Therapy (CA-CBT)
Duration: 10 1-hour sessions
Delivery: Group format, delivered by two psychologists.
n = 13 (0 lost to follow-up)
Not applicable Depression Measures:
BDI
Anxiety Measures:
SCARED
Timings:
1-week pre-treatment
1-week post-treatment
2-months post-treatment
Goodkind, LaNoue & Milford (2010)
Pilot study
Setting: School-based, USA
Participants: n = 24
Age: 12–15 (M: 13.39, SD: NR)
Gender: 7 males, 16 females
Diagnosis: Past trauma experience. Specific screening criteria and cut-off scores unclear
Cognitive Behavioural Intervention for Trauma in Schools (CBITS)
Duration: 10 weekly sessions
Delivery: Group-format delivered by a member of clinical staff and a cofacilitator
n = 23 (1 lost to follow-up)
Not applicable Depression Measures:
CDI
Anxiety Measures:
MASC
Timings:
Pre-treatment
End of treatment
3-months post-treatment
6-months post-treatment
Morsette et al. (2009) Setting: Rural American Indian Reservation, USA
Participants: n = 7 (only 4 completed)
Age: 11 to 12 years (M, SD: NR)
Gender: NR
Diagnosis: Posttraumatic Stress Disorder (PTSD) and symptoms of depression with history of trauma
Culturally adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS)
Duration: 10-week course of CBITS—Cognitive Behavioral Intervention for Trauma in Schools
Delivery: Group-format
n = 7 (3 lost to follow-up)
Not applicable Depression Measures:
CDI
Anxiety Measures:
CPSS
Timings:
Baseline
Pre-treatment
Post-treatment
Orgilés, Fernández-Martínez, Espada & Morales (2019)
One-group quasi-experimental design
Setting: School-based, Spain
Participants: n = 119
Age: 8–12 (M = 9.39; SD = 1.26)
Gender: 68 males (57.1%) and 51 females (42.9%),
Diagnosis: ≥4 on emotional symptoms subscale of the SDQ–parent version
Spanish adapted super skills for life (SSL) intervention for the prevention of anxiety and depression
Duration: 8 45-minute weekly sessions over 8 weeks
Delivery: Group-format delivered by 6 psychologists
n = 119 (9 lost to follow-up)
Not applicable Depression Measures:
CDI
Anxiety Measures:
SCARED
CALIS-C
Timings:
Pre-treatment
End of treatment
1-year post-treatment
Case studies
Binkley & Koslofsky (2016) Setting: Clinic-based, USA
Participants: n = 1
Age: 17
Gender: Female
Diagnosis: Diagnosis of moderate MDD with comorbid bulimia nervosa
Family-Based Therapy for Bulimia Nervosa (FBT-BN)
Duration: 5 sessions over 3 months
Delivery: Delivered face-to-face, information about delivering clinician NR
n = 1
Not applicable Depression Measures:
CDI
Anxiety Measures:
N/A
Timings:
1-month post-treatment
Duarté -Vélez, Bernal & Bonilla (2010)
(Case study within larger RCT)
Setting: NR, Puerto Rico
Participants: n = 1
Age: 16 years
Gender: Male
Diagnosis: Major Depressive Disorder (MDD), non-specified anxiety disorder and Attention Deficit and Hyperactivity Disorder (ADHD)
Culturally adapted manual-based Cognitive Behavioural Therapy
Duration: 12 weekly sessions (with 4 optional additional sessions)
Delivery: Individually delivered by a psychotherapist
n = 1
Not applicable Depression Measures:
CDI
CDRS-R
Anxiety Measures:
N/A
Timings:
Pre-treatment
Session-by-session
End of treatment
6-months post-treatment
9-months post-treatment
12-months post-treatment
15-months post-treatment

Notes. NR: Not reported. Depression Measures: ATQ-Malay: Automatic Thoughts Questionnaire—Malay version (Oei & Mukhtar, 2008); BDI: Beck Depression Inventory (Beck, Steer & Brown, 1996); BDI-R: Beck Depression Inventory Revised (Bonilla, Bernal, Santos & Santos, 2004); CDI: Children’s depression Inventory (Kovacs, 1985; 2011); CDI-S: Children’s Depression Inventory Short Form (Vega et al., 2016); CDRS-R: Children’s depression rating scale–revised (Poznanski & Mokros, 1996); DSRS: Depression Self-Rating Scale (Birleson, 1981); K-SADS-PL: Kiddie Schedule for affective disorders present and lifetime version (Kaufman et al., 1997); SIQ-JR: Suicidal Ideation Questionnaire-Junior (Reynolds, 1988); RADS-2: Reynolds Adolescent Depression Scale–Second Edition (Reynolds, 2002); SMFQ: Short Mood and Feelings Questionnaire (Angold et al., 1995). Anxiety Measures: ADIS: The Anxiety Disorders Interview Schedule (Silveman & Albano, 1996); CALIS-C: Child Anxiety Life Interference Scale (Lyneham et al., 2013); CASI: Childhood Anxiety Sensitivity Index (Silverman et al., 1991); CSAS-C: Chinese version of the State Anxiety Scale for Children (Li & Lopez, 2007); CPSS: Child PTSD Symptom Scale (Foa et al., 2001); MASC: Multi-dimensional anxiety scale for children (March & Parker, 1999); SCARED: Screen for anxiety related emotional disorders (Birmaher et al., 1999); SCAS: C: Spence Children’s Anxiety Scale Child versions (Spence, 1998); SCAS: P: Spence Children’s Anxiety Scale Parent versions (Nauta 2004); STAIC: State-Trait Anxiety Inventory for Children (Speilberger, 1973). Depression and Anxiety Measures: RCADS: The Revised Children’s Anxiety and Depression Scale (Chorpita et al., 2000)