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. 2023 Aug 30;15(19):10031–10056. doi: 10.18632/aging.204989

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Copyright: © 2023 Ou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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EX527 dramatically blocked the efficacy of HGWD on neurological deficits and microglia polarization in MCAO rats. (A) Representative TTC staining section. (B) Quantitative analysis of infarct regions. (C) The neurological scores (mNSS). (D) Representative double-immunofluorescence staining for CD16 (red) and Iba-1 (green) markers in hippocampus. (E) Quantification of the fluorescence intensity of CD16⁺/Iba-1⁺ cells. (F) Representative double-immunofluorescence staining for CD206 (red) and Iba-1 (green) markers in the hippocampus. (G) Quantification of fluorescence intensity of CD206⁺/Iba-1⁺ cells. Scale bar: 50 μm. ^##P < 0.01 vs. control group; **P< 0.01 vs. model group.