Fig. 5. Adaptive sampling can reduce turnaround time.

a, Five samples were run with adaptive sampling on half of the available channels. Box plots indicate the number of 450K array CpG probe sites during sequencing, normalized to the amount of available sequencing channels; minimum and maximum bounds represent the 25th and 75th percentiles, respectively; and the center bound represents the median; whiskers extend to 1.5 times the interquartile range. Dots indicate the underlying data. b, Robustness analysis results of sample PMC 68 on adaptive (left) and non-adaptive (right) channels (results for all samples are presented in Supplementary Fig. 24). Reads were accumulated in resampled orders (n = 100) at a rate based on the average MinION sequencing speed. Sturgeon was then applied to all permutations. Colours indicate the type of prediction made by Sturgeon: plain colour (correct class and score ≥0.95), darkened colour (correct class and score <0.95) and grey (incorrect class and score <0.95).