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. 2023 Oct 4;622(7984):834–841. doi: 10.1038/s41586-023-06611-6

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Large field view of cells plated on grid glass bottom dish in merged bright and fluorescent channels. M marks the grid with cells of interest. b, zoom-in view of cells within the boxed region in (a). c, composite Z-stack view of cells expressing Hbb-EGFP in (b) by confocal microscopy. Scale bar: 10 μm. d, ultra-thin section image of cells within the field of (a) by scanning electron microscopy. e, zoom-in view of cells within the boxed region in (d). Scale bar: 50 μm. f, split confocal images for the cells of interest in (c) from a row of bottom-up with a Z-step of 0.15 μm. the images within red box are corresponding to the view in (e). g, zoom-in view of image within the boxed region in (f). Hbb-EGFP condensates are indicated as R1 and R2. Scale bar: 10 μm. h, scanning electron microscopy image (left) corresponding to the confocal image (g). Scale bar: 10 μm. R1 and R2 regions are displayed in the right in zoomed view. Scale bar: 500 nm. i, Hbb condensate identified by immune electron transmission microscopy. Boxed regions are zoomed in the right. Scale bars are indicated. j, Lipid droplets detected by electron transmission microscopy. Boxed regions are zoomed in the right. Scale bars are indicated.