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. 2023 Oct 25;14:6559. doi: 10.1038/s41467-023-42276-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Schematic diagram of the experimental design. b (Left) Representative voltage traces recorded from PT neurons in response to current step injections. (Right) The intrinsic excitability of PT neurons, as quantified by input resistance (left), rheobase (middle), and spike frequency (right). 16p11^wt;Cnr1^+/+ (n = 9 cells in 2 mice), 16p11^wt;Cnr1^flox/flox (n = 5 cells in 3 mice), 16p11^dup;Cnr1^+/+ (n = 6 cells in 2 mice), and 16p11^dup;Cnr1^flox/flox (n = 8 cells in 3 mice). ***p < 0.001, **p < 0.01, *p < 0.05 (p values are (Left) 16p11^wt;Cnr1^+/+ versus 16p11^dup;Cnr1^+/+: p = 0.0042, 16p11^wt;Cnr1^+/+ versus 16p11^dup;Cnr1^flox/flox: p = 0.0001, 16p11^dup;Cnr1^+/+ versus 16p11^dup;Cnr1^flox/flox: p < 0.0001, (Right) 16p11^wt;Cnr1^+/+ versus 16p11^dup;Cnr1^+/+: p = 0.0016, 16p11^wt;Cnr1^+/+ versus 16p11^dup;Cnr1^flox/flox: p = 0.0396, 16p11^dup;Cnr1^+/+ versus 16p11^dup;Cnr1^flox/flox: p < 0.000¹ determined by two-way ANOVA with post hoc Tukey test. c (Left) Representative voltage traces recorded from IT neurons in response to current step injections. (Right) The intrinsic excitability of IT neurons, as quantified by input resistance (left), rheobase (middle), and spike frequency (right). 16p11^wt;Cnr1^+/+ (n = 4 cells in 2 mice), 16p11^wt;Cnr1^flox/flox (n = 4 cells in 2 mice), 16p11^dup;Cnr1^+/+ (n = 6 cells in 2 mice), and 16p11^dup;Cnr1^flox/flox (n = 5 cells in 2 mice). d Sociability phenotypes (left) and preference of social novelty (right) as indicated by the discrimination index in the three-chamber social interaction test. e, Time spent with an ovariectomized female mouse in the 5-trial social memory test. d, e 16p11^wt;Cnr1^+/+ (n = 6 mice), 16p11^wt;Cnr1^flox/flox (n = 5 mice), 16p11^dup;Cnr1^+/+ (n = 6 mice), 16p11^dup;Cnr1^flox/flox (n = 6 mice). d, e ***p < 0.001, **p < 0.01 (p values are (d) 16p11^wt;Cnr1^+/+ versus 16p11^dup;Cnr1^+/+: p < 0.0001, 16p11^wt;Cnr1^+/+ versus 16p11^dup;Cnr1^flox/flox: p = 0.0004, 16p11^dup;Cnr1^+/+ versus 16p11^dup;Cnr1^flox/flox: p = 0.0026, (e) Cnr1^flox/flox x 16p11dup interaction for Trial 4 [F_1,19 = 11.30, p = 0.0033], Cnr1^flox/flox x 16p11dup interaction for Trial 5 [F_1,19 = 4.760, p = 0.0419]), determined by two-way ANOVA with post hoc Tukey test. Each symbol represents one cell (b, c) and one animal (d, e). Data are presented as the mean ± s.e.m.