Table 2.
Subdistribution hazard ratios of the additional predictors
| Predictor | Subdistribution hazard ratio (95% CI) |
|---|---|
| Ankle–brachial index (<0.9) | 1.46 (1.18–1.80) |
| Body mass index (kg/m2)† | 1.02 (0.81–1.32) |
| CAC percentile† | 1.78 (1.53–2.00) |
| History of cancer | 1.07 (1.00–1.13) |
| Carotid stenosis (>25%) | 1.54 (1.22–1.94) |
| Carotid intima-media thickness (mm)‡ | 1.02 (0.92–1.14) |
| Estimated GFR (mL/min/1.73m2)† | 0.91 (0.56–1.48) |
| CRP (mg/L)* | 1.31 (1.28–1.35) |
| History of chronic inflammatory disease | 0.95 (0.54–1.67) |
| Lower education level | 1.30 (1.18–1.43) |
| Parental history of myocardial infarction | 1.36 (1.20–1.53) |
| Former smoking (vs. never) | 1.05 (1.00–1.09) |
| Gestational hypertension | 1.15 (0.97–1.36) |
| Lp(a) (mg/dL)* | 1.14 (1.12–1.17) |
| Albuminuria (>30 mg/g) | 1.34 (1.26–1.43) |
| Number of drugs (n)† | 1.18 (1.05–1.32) |
| NT-ProBNP (pg/mL)* | 1.47 (1.37–1.57) |
| hs-Troponin-T (pg/mL)* | 1.55 (1.44–1.68) |
Predictors marked with (*) are log-transformed, predictors marked with (†) are squared, and predictors marked (‡) are linear. For all these continuous predictors, the subdistribution hazard ratios are presented as third vs. first quartile. To aid clinical interpretation, squared and log coefficients are additionally displayed in Supplementary material online, Table S3.
GFR, glomerular filtration rate [calculated with Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula]; CAC, coronary artery calcium percentile; cIMT, carotid intima-media thickness; CRP, C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp(a), lipoprotein(a); NT-proBNP, N-terminal pro-B-type natriuretic peptide.