Table 1.
Demographic, Cognitive, and PET Data of Sample (n = 61)
| Demographic/Cognitive Variable | Noncarriers (n = 32) |
All PSEN1 Carriers (n = 29) |
Cognitively Unimpaired PSEN1 Carriers (n = 22) |
Test statistic, p-value |
|---|---|---|---|---|
| Age (Years) | 34.94 (6.09) | 37.21 (6.45) | 34.77 (5.28) | U = 362.5, p = .14 |
| Male/Female | 14:18 | 12:17 | 10:12 | X2 = 0.04, p = .85 |
| FAST Rating of <3 vs. FAST Rating of 3 | 32:0 | 22:7 | 22:0 | X2 = 12.13, p = .007* |
| Education (Years) | 10.94 (4.03) | 9.55 (4.27) | 10.00 (4.00) | U = 376.5, p = .20 |
| MMSE Total Score | 28.94 (0.91) | 26.93 (3.31) | 28.45 (1.06) | U = 261, p = .002* |
| Animals Total Score | 20.38 (3.56) | 20.24 (5.04) | 21.27 (4.83) | U = 463, p = .99 |
| Animals in Clusters | 12.94 (3.80) | 12.24 (5.55) | 13.68 (5.13) | U = 417, p = .50 |
| Number of Switches Between Clusters | 10.41 (2.71) | 11.31 (3.15) | 11.36 (3.04) | U = 383, p = .24 |
| Amyloid PET | 1.04 (0.03) | 1.30 (0.17) | 1.24 (0.13) | U = 16, p = <.001** |
| Inferior Temporal Tau | 1.11 (0.07) | 1.26 (0.29) | 1.14 (0.09) | U = 283, p = .009* |
| Entorhinal Tau | 1.04 (0.07) | 1.31 (0.30) | 1.22 (0.24) | U = 179, p = <.001** |