p < .01
p < .001.
Notes: Test statistics and p-values were generated for the comparison between noncarriers and all PSEN1 E280A carriers. The cognitively unimpaired carrier group is a subset of the full group of mutation carriers. Abbreviations: MMSE = Mini-Mental State Examination; FAST = Functional Assessment Staging Scale; PET = positron emission tomography; PSEN1 = presenilin1.