STUDY DESIGN	Treatment Group		Comparison Group 1		Comparison group 2…N/A
Selection bias: ·         Sequence generation   ·         Allocation concealment	Adequate/Inadequate/Unclear   Adequate/Inadequate/Unclear		Adequate/Inadequate/Unclear   Adequate/Inadequate/Unclear		Adequate/Inadequate/Unclear   Adequate/Inadequate/Unclear
Performance Bias ·         Blinding of participants   ·         Blinding of other personnel	Yes/No/Unclear   Yes/No/Unclear		Yes/No/Unclear   Yes/No/Unclear		Yes/No/Unclear   Yes/No/Unclear
Detection Bias ·         Use of outcome measure(s) apparent   ·         Blinding of outcome assessors	Yes/No/Unclear     Yes/No/Unclear		Yes/No/Unclear     Yes/No/Unclear		Yes/No/Unclear     Yes/No/Unclear
Reporting Bias ·         Time lag to publication ·         Language (Please state) ·         Duplicate publication ·         Citation reporting ·         Outcome reporting	Yes/No/Unclear   ___________________ Yes/No/Unclear   Yes/No/Unclear   Yes/No/Unclear		Yes/No/Unclear   _____________________ Yes/No/Unclear   Yes/No/Unclear   Yes/No/Unclear		Yes/No/Unclear   ___________________ Yes/No/Unclear   Yes/No/Unclear   Yes/No/Unclear
Attrition Bias ·         Incomplete outcome data   ·         Reasons specified	Yes/No/Unclear   Yes/No/Unclear		Yes/No/Unclear   Yes/No/Unclear		Yes/No/Unclear   Yes/No/Unclear
Intention to Treat	All participants entering trial	15% or fewer excluded	More than 15% excluded	Not analysed as ‘intention‐to‐treat’	Unclear	Were withdrawals described?    Yes  Š No Š         No Š                        not clear  Š