TABLE 2.
Effects of AmB formulations on promastigotes in vitroa
| Formulation and AmB concn (μM) | % Parasite death
|
|||
|---|---|---|---|---|
| 5% EtOHb | 10% EtOH | 25% EtOH | DDW | |
| Amphocil | ||||
| 1 | 99 ± 2 | 98 ± 2 | 97 ± 4 | 99 ± 1 |
| 0.3 | 78 ± 13 | 62 ± 25 | 65 ± 31 | 81 ± 5 |
| 0.1 | 25 ± 25 | 33 ± 13 | 35 ± 11 | 21 ± 15 |
| 0.03 | 11 ± 11 | 0 | 6 ± 6 | 3 ± 3 |
| Fungizone | ||||
| 1 | 100 ± 0 | |||
| 0.1 | 96 ± 4 | |||
| 0.01 | 85 | |||
| 0.001 | 6 | |||
L. major promastigotes were grown at 28°C in the presence of ethanolic Amphocil or Fungizone. The results are presented as percent death of parasites (average ± standard error) determined after 24 h.
EtOH, ethanol.