Table 2.
Adjusted linear regression analysis comparing absolute and relative neurometabolite concentrations in parietal gray matter (40 CHEU, 98 CHU) and parietal white matter (25 CHEU, 84 CHU).
| Voxel | Metabolite | B | SE | Value of p | Metabolite | B | SE | Value of p |
|---|---|---|---|---|---|---|---|---|
| Parietal gray matter | NAA a | −0.02 | 0.26 | 0.925 | NAA/Cr+PCr | −0.004 | 0.02 | 0.831 |
| Glu b | −0.64 | 0.32 | 0.046 | Glu/Cr+PCr f | −0.06 | 0.03 | 0.035 | |
| Ins c | −0.13 | 0.13 | 0.346 | Ins/Cr+PCr | −0.01 | 0.01 | 0.260 | |
| GPC+PChd | −0.01 | 0.03 | 0.549 | GPC+PCh/Cr+PCr | −0.003 | 0.002 | 0.202 | |
| Cr+PCr e | −0.003 | 0.13 | 0.978 | |||||
| NAA g | −0.31 | 1.12 | 0.781 | NAA/Cr+PCr | −0.017 | 0.025 | 0.491 | |
| Glu h | 3.35 | 1.95 | 0.089 | Glu/Cr+PCr f | −0.006 | 0.044 | 0.892 | |
| Parietal white matter | Ins i | −0.35 | 0.71 | 0.623 | Ins/Cr+PCr | 0.005 | 0.017 | 0.734 |
| GPC+PCr j | −0.08 | 0.14 | 0.562 | GPC+PCh/Cr+PCr | −0.010 | 0.005 | 0.039 | |
| Cr+PCr k | 0.08 | 0.98 | 0.934 |
Outliers removed from the analysis: a 5 CHU and 1 CHEU, b 5 CHU and 2 CHEU, c 6 CHU and 7 CHEU, d 5 CHU and 3 CHEU, e 5 CHU and 1 CHEU, f 2 CHU, g 13 CHU and 10 CHEU, h 9 CHU and 6 CHEU, I 11 CHU and 10 CHEU, j 14 CHU and 10 CHEU, k 10 CHU and 9 CHEU. Unstandardised coefficient, B; Standard error, SE; value of p, p; CHEU, children who are HIV-exposed uninfected; NAA, N-acetyl aspartate; Glu, Glutamate; Ins, myo-inositol; GPC+PCh, total choline (glycerophosphocholine+phosphocholine); Cr+PCr, total creatine (creatine+phosphocreatine); coefficients significant at p < 0.05 in bold font. Adjusted for age at scan, sex and maternal alcohol use during pregnancy.