Figure 2.

SCs support axons during development, homeostasis, and repair by several means. The plasticity of SCs allows these cells to have critical participation in supporting axons during development, maintenance, and nerve regeneration. Several functions have been identified in order for SCs to promote axonal regeneration after injury or disease onset The main known functions are neurotrophic factors (NTFs) and cytokines release, remyelination, neuroprotection/axonoprotection, secretion of extracellular vesicles for cell–cell or cell-axon communications, and also transportation of lactate and ribosome between SCs and axons.