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. 2023 Oct 12;17:1248922. doi: 10.3389/fncel.2023.1248922

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Copyright © 2023 Oliveira, Yanick, Wein and Gomez Limia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro and in vivo protocols for generating SCs and investigating SC-neuron interaction. In vitro protocols use primary SCs, SC lines, SCs generated from direct reprogramming, or SCs derived from iPSCs. These in vitro protocols are used to investigate candidate therapeutic drugs and to study pathomechanisms of neuropathies (A). In vivo preclinical studies involve the use of animal models of neuropathies and peripheral nerve injuries. Currently, different therapies such as gene therapy and immunotherapies have been explored in preclinical trials (B).