Table 2.
Proteins involved in immature and mature SCs stages and neuronal interaction.
| Protein | Main function | Type of cell | Reference |
|---|---|---|---|
| S100B | Proliferation, differentiation, apoptosis, calcium homeostasis, energy metabolism, inflammation response, and migration through interactions with several target proteins including enzymes, cytoskeletal subunits, receptors, transcription factors | Immature and mature SCs | Donato et al. (2013) |
| GALC | Involved with macrophage interaction to perform myelin debris degradation | SCs interaction with macrophages | Weinstock et al. (2020) |
| GFAP | Proliferation | Development, non-myelinating SCs, immature SCs | Chen et al. (2007) |
| KROX20 | Activated by Oct6 and Brn2, acting in the promyelinating stage blocks proliferation of SCs | Myelinating SCs | Topilko et al. (1994) |
| p75 (NGFR) | Neuroprotein receptor | Myelinating SCs | Gonçalves et al. (2020) |
| PLP | Conform the major structural myelin. It is required for the long-term preservation of myelinated axons | Myelinating SCs | Patzig et al. (2016) |
| PMP22 | Preferentially expressed in PNS | Myelinating SCs | Mittendorf et al. (2017) |
| ERBB2/ERBB3 | Neurotic network to myelination, promyelin TF, cell migration receptor of nrg1 | Myelinating SCs | Lyons et al. (2005) |
| P0/MPZ | Promyelin TF, associated with Sox10 and Egr2 | Myelinating SCs | LeBlanc et al. (2007) |
| Cnx32 | Directly regulated by Sox10 | Myelinating SCs | Bondurand (2001) |
| Oct-6/Pou3f1 | Promyelin TF, when inhibited there is a transient delay in myelination | SCPs precursors | Donato et al. (2013) Topilko et al. (1994) |
| Brn2/Pou3f2 | Promyelin TF, compensates lack of Oct-6 | SCPs precursors | Donato et al. (2013) |
| NFkB | Promyelin TF | SCs | Morton et al. (2013) |
| Sox10 | Development/promyelin TF, new targets: ARPC1A, CHN2, DDR1, GAS7 (genes associated with PNS) | SCs | Fogarty et al. (2020) |
| Nab 1 and 2 | Receptors of Egr2, repress Erg2 | SCs | Srinivasan et al. (2007) |
| Nrg1 | SC growth and differentiation | Neuron interaction with SCs | Fricker and Bennett (2011) |
| Prx | Promyelin TF encodes 2 PDZ-domain proteins, required for maintenance of peripheral nerve myelination | SCs | Wang et al. (2018) |
| Cnp, Mal, Mapk3 | Differentiation and myelination | SCs | Cervellini et al. (2018) |
| Mbp | Promyelin TF | SCs | García-Suárez et al. (2009) |
S100B, S100 calcium Binding protein b; GALC, galactosylceramidase; GFAP, glial fibrillary acidic protein; NGFR, nerve growth factor receptor; PMP22, peripheral myelin protein 22; PLP, proteolipid protein 1; Erbb3, Erb-B3 receptor tyrosine kinase 3; P0/Mpz, myelin Protein 0; Cnx32, connexin32; Oct-6/Pou3f1, Oct-6/POU domain, class 3, transcription factor 1; NFkB, nuclear factor – kB; Sox10, SRY-box transcription factor 10; Nab1 and 2, NGFI-a-binding protein 1 and 2; Nrg1, neuregulin 1; Prx, periaxin; Cnp, C-type natriuretic peptide; MaL, myelin and lymphocyte protein; Mapk3, mitogen-activated protein kinase 3;MBP, myelin basic protein.