Table 2. Biliary excretion profiles of enrofloxacin (ERFX), orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) after intravenous injection (5 mg/kg BW) in rabbits (n=5). Ciprofloxacin (CPFX), metabolite of ERFX, simultaneously detected with ERFX in bile after ERFX injection.
| ERFX Mean ± SD | CPFX Mean ± SD | OBFX Mean ± SD | MBFX Mean ± SD | OFLX Mean ± SD | |
|---|---|---|---|---|---|
| Cmax in bile (µg/mL) | 6.09 ± 1.96 | 3.56 ± 0.78 | 14.4 ± 2.2 | 10.8 ± 1.1 | 17.1 ± 2.7 |
| CLbile (L/hr/kg) | 0.0048 ± 0.0010 | 0.0199 ± 0.0054 | 0.0050 ± 0.0013 | 0.0057 ± 0.0012 | 0.0094 ± 0.0011 |
| CLbile / CLtot (%) | 0.48 ± 0.15 | -* | 1.21 ± 0.37 | 2.14 ± 0.21 | 2.32 ± 1.06 |
| Amount excreted in bile0-8hr (μg/kg BW) | 20.2 ± 6.85 | 31.4 ± 6.8 | 50.0 ± 15.6 | 69.1 ± 11.4 | 71.7 ± 8.49 |
| Cumulative bile excretion of each drugs of dose0-8hr (%) | 1.09 ± 0.27** | 0.99 ± 0.31 | 1.38 ± 0.22 | 1.43 ± 0.17 |
* Total body clearance of CPFX cannot be calculated because CPFX is a metabolite of ERFX. ** Sum of ERFX and CPFX found in the bile for 8 hr of administered dose as ERFX.