Figure 1. Number of Genes Tested and Proportion of Variants of Uncertain Significance (VUSs).

A, Only 29 409 individuals (1.7%) were tested for a single gene; 16 448 individuals (1.0%) were tested for more than 400 genes and have been excluded from the x-axis. Of note, the 2 highest proportions of individuals tested, encompassing 47 genes and 84 genes, each, represent the 2 highest volume hereditary cancer panels. C, Slope of each line was calculated using a linear regression model, with the SE shown as shading around the line. Definitions of relevant terms are provided in the eAppendix in Supplement 1.