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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: Methods Mol Biol. 2023;2660:85–94. doi: 10.1007/978-1-0716-3163-8_7

Figure 1.

Figure 1.

General Network Analysis Pipeline. Sensitive and resistant samples are subjected to scRNA-seq, followed by subjecting the scRNA-seq data in combination with transcription factor (TF) motifs and protein-protein interactions (PPI), derived from established databases, to PANDA analysis. This will lead to identifications of a generalized drug resistance network which can then be subjected to gene set enrichment analysis (GSEA) and connectivity map analysis (CMAP) to identify drug resistance pathways and candidate drugs, respectively.