Table 2.
Comparison of demographic and baseline characteristics of patients in low-dose vs. standard-dose thrombolytic therapy groups
| Low-dose, n=19 (17.4%) | Standard-dose, n=90 (82.6%) | Test statistic | Total, n=109 | p | |
|---|---|---|---|---|---|
| Age (years) >65 |
68 (42–91)/47.74 12 (63.2) |
74 (35–92) /56.53 63 (70) |
717 0.09 |
73 (35–92) 75 (68.8) |
0.27a 0.75b |
| Gender, n (%) Female Male |
8 (42.1) 11 (57.9) |
46 (51.1) 44 (48.9) |
0.21 |
54 (49.5) 55 (50.5) |
0.64b |
| Vascular risk factors, n (%) Hypertension Diabetes Hyperlipidemia Atrial Fibrillation CAD Smoking |
13 (68.4) 2 (10.5) 7 (36.8) 9 (47.4) 4 (21.1) 5 (26.3) |
59 (65.6) 30 (33.3) 24 (26.7) 41 (45.6) 24 (26.7) 33 (36.7) |
.00 3.93 0.37 0.00 - 0.35 |
72 (66.1) 32 (29.4) 31 (28.4) 50 (45.9) 28 (25.7) 38 (34.9) |
1b 0.08b 0.54b 1b 0.77c 0.55b |
| SBP (mmHg) | 146 (115–220)/53.68 | 150 (80–200)/55.28 | 830 | 150 (80–220) | 0.84a |
| DBP (mmHg) | 85 (70–120)/65.74 | 80 (60–120)/52.73 | 651 | 83 (60–120) | 0.09a |
| Blood glucose level (mg/dL) | 127 (97–194)/ 51.26 | 132 (78–363)/ 55.79 | 974 | 130 (78–363) | 0.57a |
| Acetyl salicylic acid use, n (%) | 5 (26.3) | 22 (24.4) | - | 27 (25) | 0.54c |
| History of stroke | 2 (10.5) | 4 (4.4) | - | 6 (5.5)22 | 0.28c |
| Clinical stroke type, n (%) TACI PACI POCI Lacunar |
8 (42.1) 9 (47.4) 1 (5.3) 1 (5.3) |
46 (51.1) 32 (35.6) 6 (6.7) 6 (6.7) |
1.52 |
54 (49.5) 41 (37.6) 7 (6.4) 7 (6.4) |
0.67d |
| S/N time (min) | 150 (79–270)/59.63 | 150 (60–270)/54.02 | 767 | 150 (60–270) | 0.48a |
| NIHSS (pre-treatment) | 12 (3–20)/42.29 | 15 (5–26)/57.68 | 613 | 14 (3–26) | 0.053a |
CAD: Coronary artery disease; DBP: Diastolic blood pressure; Min.: Minimum; Max.: Maximum; NIHSS: The national institutes of health stroke scale score; S/N: Symptom/needle; SBP: Systolic blood pressure; TACI: Total anterior circulation infarct; PACI: Partial anterior circulation infarct; POCI: Posterior circulation infarct; Data were expressed as median (minimum: maximum)/mean Rank and n (%); a: Mann Whitney U Testi; b: Continuity correction; c: Fisher’s Exact Test; d: Pearson Chi-Square.