TABLE 1.

Ritonavir pharmacokinetic parameters after administration of ritonavir alone or with fluoxetine^a

Ritonavir administration	Tmax (h)	Cmax (μg/ml)b	AUC∞ (μg · h/ml)c	β (h−)d	t1/2 (h)e
Alone	4.4 ± 1.2	13.12 ± 3.39	128.1 ± 34.1	0.145 ± 0.026	4.78
With fluoxetine	4.2 ± 0.8	12.53 ± 2.85	152.3 ± 33.0	0.137 ± 0.014	5.07

^aThe values shown are means ± SD (n = 16). 

^bRatio of means, 0.955; 95% CI for the ratio of means, 0.850 to 1.076. 

^cRatio of means, 1.190; 95% CI for the ratio of means, 1.065 to 1.338. 

^dCalculated by using ritonavir concentrations in plasma from 18 to 24 h postdosing. 

^eReported as a harmonic mean.