Table 2.
Long-term health outcomes for Q-fever fatigue syndrome patients assisted at Q-support Netherlands, 2021
| Total (n = 368) |
Patients < 40 years old (n = 43) |
Patients 40–<65 years old (n = 237) | Patients ≥ 65 years old (n = 88) |
P-value for difference | |
|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | ||
| Number of long-term complaints | 12.0 (8.0–16.0) | 13.0 (9.0–18.0) | 12.0 (8.0–16.0) | 11.0 (7.0–14.0) | 0.043 |
| Health-related quality of life | |||||
| EQ-5D-5L index | 0.63 (0.38–0.75) | 0.67 (0.41–0.74) | 0.61 (0.33–0.74) | 0.68 (0.50–0.78) | 0.018 |
| EQ-VAS | 50.0 (34.3–61.8) | 40.0 (30.0–60.0) | 46.0 (30.0–60.0) | 60.0 (41.5–70.0) | <0.001 |
| Fatigue | |||||
| MFI-20 total score | 74.0 (65.0–84.0) | 77.0 (66.0–83.0) | 76.0 (67.0–85.0) | 69.0 (61.3–76.0) | <0.001 |
| General fatigue | 18.0 (15.0–20.0) | 19.0 (18.0–20.0) | 18.0 (15.0–20.0) | 16.0 (14.0–19.0) | <0.001 |
| Physical fatigue | 16.0 (14.0–19.0) | 17.0 (15.0–19.0) | 16.0 (14.0–19.0) | 15.0 (13.0–17.0) | 0.001 |
| Reduction in activity | 14.0 (12.0–17.0) | 14.0 (10.0–17.0) | 15.0 (12.0–17.0) | 14.0 (10.0–16.0) | 0.029 |
| Reduction in motivation | 12.0 (9.3–15.0) | 11.0 (9.0–14.0) | 12.0 (10.0–15.0) | 12.0 (8.3–13.0) | 0.013 |
| Cognitive fatigue | 14.0 (12.0–17.0) | 15.0 (12.0–18.0) | 15.0 (12.0–17.5) | 13.0 (11.0–16.0) | <0.001 |
| Depression | 0.018 | ||||
| PHQ-2 score | 2.0 (1.0–3.0) | 2.0 (1.0–2.0) | 2.0 (1.0–3.0) | 1.0 (0.0–2.0) | |
| Depression likely (score ≥ 3) (n (%)) | 101 (27.4%) | 8 (18.6%) | 80 (33.8%) | 13 (14.8%) | |
| Anxiety | 0.025 | ||||
| GAD-2 score | 1.0 (0.0–2.0) | 1.0 (0.0–3.0) | 1.0 (0.0–2.0) | 0.0 (0.0–2.0) | |
| Anxiety likely (score ≥ 3) (n (%)) | 79 (21.5%) | 11 (25.6%) | 57 (24.1%) | 11 (12.5%) | |