表5.
46例SMARCA4-DNSCLC患者PFS单因素与多因素Cox回归分析
| Characteristics | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | ||
| Age (<65 yr vs ≥65 yr) | 0.508 (0.205-1.261) | 0.144 | |||
| ECOG PS (0-1 vs 2) | 1.068 (0.436-2.618) | 0.885 | |||
| Smoking (Yes vs No) | 0.139 (0.032-0.603) | 0.008 | 0.110 (0.020-0.589) | 0.010 | |
| Family history (Yes vs No) | 0.293 (0.093-0.921) | 0.036 | 0.569 (0.165-1.965) | 0.373 | |
| Location (Central vs Peripheral) | 1.518 (0.604-3.815) | 0.374 | |||
| TNM stage (III vs IV) | 0.829 (0.337-2.041) | 0.683 | |||
| T stage (1-2 vs 3-4) | 1.390 (0.553-3.493) | 0.484 | |||
| Brain metastasis (Yes vs No) | 0.525 (0.220-1.255) | 0.147 | |||
| Bone metastasis (Yes vs No) | 1.971 (0.712-5.452) | 0.191 | |||
| Adrenal metastasis (Yes vs No) | 0.342 (0.123-0.953) | 0.040 | 0.419 (0.146-1.203) | 0.106 | |
| Erythrocytes | 0.531 (0.218-1.293) | 0.163 | |||
| Prothrombin time | 1.118 (1.013-1.234) | 0.027 | 1.092 (0.978-1.220) | 0.118 | |
| D-Dimer | 1.252 (0.838-1.871) | 0.272 | |||
| LDH (>245 U/L vs ≤245 U/L) | 0.670 (0.293-1.534) | 0.343 | |||
| CA724 (>6.9 ng/mL vs ≤6.9 ng/mL) | 0.526 (0.229-1.208) | 0.130 | |||
| CA211 (>3.3 ng/mL vs ≤3.3 ng/mL) | 0.698 (0.304-1.603) | 0.397 | |||
| CEA (>5 ng/mL vs ≤5 ng/mL) | 0.548 (0.229-1.312) | 0.177 | |||
| Ki-67 (>30% vs ≤30%) | 0.500 (0.190-1.311) | 0.158 | |||
| Treatment (Chemotherapy vs PD-1 ICIs plus chemotherapy) | 2.605 (1.007-6.742) | 0.048 | 4.275 (1.238-14.756) | 0.022 | |
| Cisplatin (Yes vs No) | 1.033 (0.300-3.557) | 0.959 | |||