Table 1.
Finemapped associations
| Molecular name | Tissue (finemapped model) | Ref name | Zfinemap | PIP | ZTWAS (P) -tissue | ZPWAS (P) -tissue | Region | Credible set size (brain/ default) |
|---|---|---|---|---|---|---|---|---|
| MST1 | Blood plasma protein | GTEx | −4.63 | 0.457 | 4.85 (1.2 × 10−6)- hypothalamus – Conditionally independent | −3.4787 (5.04 × 10−4) -plasma | 3: 49 317 941–3: 51 830 833 | NA/1 |
| WDR6 | Brain dorsolateral prefrontal cortex | PsychENCODE | 6.46 | 0.997 | 7.44 (9.96 × 10−14)- cortex – Conditionally independent | NA | 3: 49 317 338–3: 51 828 635 | 1/1 |
| RP13-238F13.5 | Brain spinal cord cervical c-1 | GTEx | 5.01 | 0.97 | NA | NA | 10: 125 919 795–10: 127 999 424 | 1/1 |
| NXPE1 | Testis | GTEx | 6.02 | 1 | NA | NA | 11: 114 833 710–11: 116 383 064 | 1/1 |
| C3orf62 | Brain dorsolateral prefrontal cortex | CommonMind Consortium | −7.19 | 0.423 | −7.13 (9.71 × 10−13)- cortex | NA | 3: 47 777 774–3: 49 313 978 | 4/384 |
| TREX1 | Brain cortex | GTEx | −6.95 | 0.449 | −3.2575 (1.1 × 10−3) – Nucleus accumbens basal ganglia | −2.1349 (0.032) -DLPFC | 3: 49 317 338–3: 51 815 687 | 5/476 |
| PROS1 | Brain cortex | GTEx | 5.21 | 0.895 | 0.07 (0.94) -whole blood | NA | 3: 94 256 654–3: 95 306 175 | 2/3 |
| PRKAR2A | Artery tibial | GTEx | −6.95 | 0.814 | NA | NA | 3: 49 317 338–3: 51 815 687 | 5/476 |
Finemapped genes with moderate or strong evidence of a causal effect on AN (PIP > 0.4). Tissue indicates which tissue the expression weights were derived from, Ref name indicates the group/consortium responsible for eQTL generation, Zfinemap indicates the estimated Z score association, PIP indicates the posterior inclusion probability and region indicates the GRCh37 genomic region the credible set was derived from. Credible set size indicates the number of genes in the credible set when prioritising brain or any tissue. All genes are in the credible set. ZTWAS (P) -tissue and ZPWAS (P) -tissue indicates the TWAS and PWAS Z score and p value associated with the most significant tissue for each association. No spliceWAS associations are available for these eight genes.