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. 2023 Oct 10;8(42):39546–39561. doi: 10.1021/acsomega.3c05377

Table 1. Modification of the 4′-Position Group of the Propionamide Series.

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a

In-cell target engagement by the NanoBRET assay, n = 1.

b

Inhibition of MHV-nLuc replication, n = 3 with SE ± 0.1.

c

Values from ChemDraw Professional v16.0.

d

Miniaturized shake flask using CLND detection, n = 1.

e

Metabolism of the compound in primary mouse liver microsomes (MLM) calculated as 100 – (% remaining), n = 1.

f

Compound previously reported in ref (5).