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. 2023 Oct 10;8(42):39546–39561. doi: 10.1021/acsomega.3c05377

Table 3. In Vivo Mouse Pharmacokinetic Parameters of 1i, 2c, and 2ea.

  i.v.(1 mg/kg)
 i.p.(10 mg/kg)
compound Cmax (ng/mL) AUClast (ng·h/mL) Vdss (L/kg) t1/2 (h) CLint (mL/min/kg) Cmax (ng/mL) AUClast (ng·h/mL) t1/2 (h) F (%)
1i 1100 670 2.60 1.3 36 4700 7010 1.2 100
2c 350 200 5.07 1.8 84 670 770 1.5 40
2e 810 250 2.67 1.2 69 1500 1300 1.4 53
a

Mice dosed by i.v. or i.p. route of administration, n = 3. Compounds quantified by LC-MS.