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. 2023 Oct 10;8(42):39546–39561. doi: 10.1021/acsomega.3c05377

Table 4. In Vitro Mouse Metabolism of 1i, 2c, and 2ea.

compound liver microsomes CLint (mL/min/kg) S9 fraction CLint (mL/min/kg) hepatocytes CLint (mL/min/kg)
1i <24 0 143
2c <24 1 132
2e 27 4 69
a

Compounds quantified by LC-MS at five time points over 5 h, n = 1.