. Author manuscript; available in PMC: 2024 Nov 1.

Published in final edited form as: Obesity (Silver Spring). 2023 Sep 26;31(11):2762–2773. doi: 10.1002/oby.23898

Table 3.

Analytic model findings for primary outcomes.

	Continuous outcomes
Model effect	Binge Eating Frequency (EDE Interview)	Percent Weight Loss
MED	F(1,86)=0.05, p=0.83	F(1,84)=11.3, p=0.001
Time	F(1,86)=131.5, p<0.0001	F(3,229)=7.43, p<0.0001
MED*Time	F(1,86)=0.59, p=0.44	F(3,229)=3.26, p=0.02
Obesity	F(1,86)=0.87, p=0.35	F(1,84)=0.36, p=0.55
	Categorical outcomes
Model effect	Attaining Binge-Eating Remission at Posttreatment	Attaining ≥5% Weight Loss from Baseline
MED	Χ²₍₁₎=0.63, p=0.43	Χ²₍₁₎=6.30, p=0.01
Obesity	Χ²₍₁₎=1.37, p=0.24	Χ²₍₁₎=3.06, p=0.08

Note: Eating Disorder Examination (EDE) Interview administered at pre-treatment and post-treatment;

Weight measured pre-treatment, monthly throughout treatment, and post-treatment;

MED = naltrexone/bupropion versus placebo; Obesity = obesity status (non-obese, obese);

Time = assessment timepoints; continuous outcomes analyzed using mixed models on

log-transformed data; binary outcomes analyzed using logistic regression.