Table 4.
Secondary clinical measures and outcomes by treatment conditions.
| Placebo (n=46) | NB (n=43) | |||||
|---|---|---|---|---|---|---|
| n | M | SD | n | M | SD | |
| EDE Global Score | ||||||
| Pre-Treatment | 46 | 2.28 | 0.92 | 43 | 2.25 | 0.69 |
| Post-Treatment | 44 | 1.72 | 0.88 | 38 | 1.59 | 0.78 |
| Change | 44 | −0.58 | 0.74 | 38 | −0.63 | 0.71 |
| BDI-II Depression Score | ||||||
| Pre-Treatment | 46 | 15.80 | 8.62 | 43 | 13.37 | 7.96 |
| Post-Treatment | 43 | 8.67 | 9.14 | 34 | 7.00 | 5.86 |
| Change | 43 | −7.21 | 10.03 | 33 | −6.85 | 8.97 |
| TFEQ Restraint Score | ||||||
| Pre-Treatment | 46 | 8.35 | 4.56 | 43 | 8.58 | 4.86 |
| Post-Treatment | 43 | 9.51 | 5.13 | 34 | 9.94 | 4.33 |
| Change | 43 | 1.21 | 4.68 | 33 | 1.58 | 4.43 |
| TFEQ Disinhibition Score | ||||||
| Pre-Treatment | 46 | 12.91 | 2.62 | 43 | 13.14 | 2.14 |
| Post-Treatment | 43 | 10.67 | 3.54 | 34 | 10.35 | 3.88 |
| Change | 43 | −2.12 | 3.03 | 33 | −2.82 | 2.97 |
| TFEQ Hunger Score | ||||||
| Pre-Treatment | 46 | 10.63 | 2.89 | 43 | 9.67 | 2.99 |
| Post-Treatment | 43 | 8.16 | 3.85 | 34 | 7.29 | 4.12 |
| Change | 43 | −2.65 | 3.37 | 33 | −2.58 | 3.50 |
| FCI Score | ||||||
| Pre-Treatment | 46 | 1.95 | 0.76 | 43 | 1.71 | 0.46 |
| Post-Treatment | 43 | 1.43 | 0.61 | 34 | 1.18 | 0.61 |
| Change | 43 | −0.56 | 0.68 | 33 | −0.53 | 0.49 |
| PFS Score | ||||||
| Pre-Treatment | 46 | 59.02 | 12.59 | 43 | 57.81 | 10.24 |
| Post-Treatment | 43 | 47.09 | 14.96 | 34 | 45.76 | 16.75 |
| Change | 43 | −12.19 | 13.18 | 33 | −11.91 | 12.36 |
| Cholesterol Total | ||||||
| Pre-Treatment | 44 | 192.34 | 39.53 | 43 | 183.88 | 35.51 |
| Post-Treatment | 39 | 193.28 | 41.34 | 32 | 180.16 | 34.62 |
| Change | 37 | −2.78 | 26.19 | 32 | −6.94 | 21.11 |
| HDL | ||||||
| Pre-Treatment | 44 | 55.27 | 15.18 | 43 | 53.37 | 13.92 |
| Post-Treatment | 39 | 55.79 | 16.55 | 32 | 54.41 | 13.90 |
| Change | 37 | −0.43 | 11.31 | 32 | 0.09 | 7.34 |
| LDL | ||||||
| Pre-Treatment | 44 | 114.89 | 28.35 | 43 | 108.12 | 27.33 |
| Post-Treatment | 38 | 115.87 | 33.74 | 32 | 105.50 | 27.25 |
| Change | 36 | −2.00 | 19.90 | 32 | −4.31 | 17.65 |
| Triglycerides | ||||||
| Pre-Treatment | 44 | 116.43 | 66.25 | 43 | 121.84 | 70.42 |
| Post-Treatment | 39 | 122.79 | 82.57 | 32 | 105.09 | 57.59 |
| Change | 37 | 2.86 | 74.04 | 32 | −20.97 | 46.86 |
| HbA1c | ||||||
| Pre-Treatment | 44 | 5.49 | 0.69 | 42 | 5.37 | 0.48 |
| Post-Treatment | 39 | 5.61 | 0.91 | 32 | 5.39 | 0.54 |
| Change | 37 | 0.07 | 0.45 | 31 | −0.02 | 0.18 |
Note: EDE = Eating Disorder Examination Interview; BDI-II = Beck Depression Inventory-II; TFEQ =
Three Factor Eating Questionnaire; FCI = Food Craving Inventory; PFS = Power of Food Scale;
HbA1c = glycated hemoglobin A1c (%); NB = naltrexone/bupropion; N = number; M = mean; SD = standard deviation.