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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: Acta Trop. 2016 Sep 17;164:329–336. doi: 10.1016/j.actatropica.2016.09.008

Table 4.

Comparisons in proportional distributions of Chloroquine and Sulphadoxine – Pyrimethamine polymorphisms by study sites. C

Allele Polymorphism Number (%) of mutant alleles Pearson’s X2 test P value*
Ruhuha - n (%) Mubuga - n (%)
pfcrt 76T 105 (55.0) 86 (43.7) 4.971 0.026
pfmdrl 86Y 40 (21.5) 33 (16.8) 1.346 0.246
184Y 107 (62.6) 100 (57.1) 1.0611 0.303
1042C 0 0 - -
1034C 0 0 - -
1246Y 37 (20.8) 35 (17.8) 0.5497 0.458
pfdhps 613S 0 0
581G 49 (26.8) 39 (21.7)
437G 169 (91.9) 169 (93.9) 0.572 0.450
540E 173 (94.5) 170 (94.4) 0.001 0.970
pfdhfr 51I 190 (100) 185 (99.5) 2.982 0.225
59R 160 (84.2) 184 (96.3) 19.510 < 0.0001
108N 190 (100) 189 (100) - -
164L 19 (10.2) 0 (0) 20.329 < 0.0001
Grouped alleles Double pfdhps (540E-437G) 168 (91.8) 166 (92.2) 2.311 0.129
Triple pfdhfr (51I-59R-108N) 160 (84.2) 179 (96.2) 1.830 0.176
Quadruple (51I-59R-108N-164L) 18 (8.8) 0 (0.0) 17.839 < 0.0001
Quintuple pfdhfr 540E-G437G /pfdhfr 51I-59R-108N) 143 (73.7) 153 (74.6) 0.044 0.833
Sextuple pfdhfr E540-G437–581G /pfdhfr 51I-59R-108N) 42 (21.7) 31 (15.1) 2.8411 0.092
*

P value comparing proportions of mutant parasites were based on a 2-sample t-test.

Significant values are in boldface.