Table 4.
Comparisons in proportional distributions of Chloroquine and Sulphadoxine – Pyrimethamine polymorphisms by study sites. C
| Allele | Polymorphism | Number (%) of mutant alleles | Pearson’s X2 test | P value* | |
|---|---|---|---|---|---|
| Ruhuha - n (%) | Mubuga - n (%) | ||||
| pfcrt | 76T | 105 (55.0) | 86 (43.7) | 4.971 | 0.026 |
| pfmdrl | 86Y | 40 (21.5) | 33 (16.8) | 1.346 | 0.246 |
| 184Y | 107 (62.6) | 100 (57.1) | 1.0611 | 0.303 | |
| 1042C | 0 | 0 | - | - | |
| 1034C | 0 | 0 | - | - | |
| 1246Y | 37 (20.8) | 35 (17.8) | 0.5497 | 0.458 | |
| pfdhps | 613S | 0 | 0 | ||
| 581G | 49 (26.8) | 39 (21.7) | |||
| 437G | 169 (91.9) | 169 (93.9) | 0.572 | 0.450 | |
| 540E | 173 (94.5) | 170 (94.4) | 0.001 | 0.970 | |
| pfdhfr | 51I | 190 (100) | 185 (99.5) | 2.982 | 0.225 |
| 59R | 160 (84.2) | 184 (96.3) | 19.510 | < 0.0001 | |
| 108N | 190 (100) | 189 (100) | - | - | |
| 164L | 19 (10.2) | 0 (0) | 20.329 | < 0.0001 | |
| Grouped alleles | Double pfdhps (540E-437G) | 168 (91.8) | 166 (92.2) | 2.311 | 0.129 |
| Triple pfdhfr (51I-59R-108N) | 160 (84.2) | 179 (96.2) | 1.830 | 0.176 | |
| Quadruple (51I-59R-108N-164L) | 18 (8.8) | 0 (0.0) | 17.839 | < 0.0001 | |
| Quintuple pfdhfr 540E-G437G /pfdhfr 51I-59R-108N) | 143 (73.7) | 153 (74.6) | 0.044 | 0.833 | |
| Sextuple pfdhfr E540-G437–581G /pfdhfr 51I-59R-108N) | 42 (21.7) | 31 (15.1) | 2.8411 | 0.092 | |
*
P value comparing proportions of mutant parasites were based on a 2-sample t-test.
Significant values are in boldface.