Table 4.

The top 10 molecules, pathological processes and disease in the intestinal barrier field relevant to inflammatory bowel disease

Molecule	Count	Pathological process	Count	Treatment	Count
NF-kB	418	Apoptosis	292	Probiotic	237
TNF-α	329	Oxidative stress	232	Nanoparticles	77
IFN-gamma	173	Metabolism	88	Antioxidant	73
Mucin	100	Dysbiosis	83	Butyrate	70
Occludin	90	Autophagy	82	Infliximab	66
Nitric oxide	87	Infection	80	Polysaccharide	48
ZO-1	55	Bacterial translocation	68	Prebiotic	40
Claudin-2	54	Endoplasmic reticulum stress	65	Fecal microbiota transplantation	37
E-cadherin	51	Transport	59	Lactobacillus	32
Antimicrobial peptide	50	Absorption	50	Vitamin D	26

NF-kB: Nuclear factor kappa B; TNF-α: Tumor necrosis factor-α; IFN: Interferon.