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. Author manuscript; available in PMC: 2024 Aug 14.
Published in final edited form as: ACS Biomater Sci Eng. 2023 Jun 30;9(8):4916–4928. doi: 10.1021/acsbiomaterials.3c00290

Figure 3.

Figure 3.

(A) A custom NanoString code set was used to measure hMSC osteogenic and immunomodulatory and angiogenic gene expression in response to mineralized collagen scaffold glycosaminoglycan content (CS6; chondroitin-6-sulfate or Hep; heparin) as a function of initial culture conditions (basal - B or licensed - L). Gene expression is represented as a fold change compared to hMSC gene expression of basal cultured hMSCs prior to seeding (n = 3). (B) Subset of osteogenic genes (C) subset of immunomodulatory genes, (D) subset of angiogenic genes that displayed significance. * denotes significance (p < 0.05) between indicated groups of same treatment (basal or licensed), ** denotes significance (p < 0.05) between all groups of same treatment (basal or licensed),^ denotes significance (p < 0.05) between indicated groups of different treatment,^̂ denotes significance (p < 0.05) between indicated group and all other groups of other treatment, and # denotes significance (p < 0.05) of indicated group and all other groups at that time point.