Table 4.
Cox Regression Evaluation of ESI Associated with Outcomes in HBV-ACLF patients
| Outcomes | ESI (cm2/m2) | No. of events (%) | Univariate analysis | Multivariate analysis* | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Mortality | ESI<12.05 | 30(51.7) | 2.23(1.25–4.21) | 0.005 | 2.52(1.34–9.24) d | 0.011 | |
| ESI ≥ 12.05‡ | 16(26.7) | 1.00 | 1.00 | ||||
| Kidney dysfunction | ESI<12.05 | 20(43.5) | 1.47(1.01–2.15) | 0.017 | 1.36(1.05–2.93) e | 0.043 | |
| ESI ≥ 12.05‡ | 13(23.2) | 1.00 | 1.00 | ||||
| Hepatic encephalopathy | ESI<12.05 | 19(39.6) | 2.54(1.21–5.31) | 0.014 | 2.26(2.05–3.13) f | 0.036 | |
| ESI ≥ 12.05‡ | 8(14.0) | 1.00 | 1.00 | ||||
| In-hospital infection | ESI<12.05 | 27(75.0) | 1.47(0.94–2.31) | 0.090 | 1.62(0.6–3.08) g | 0.138 | |
| ESI ≥ 12.05‡ | 26(63.4) | 1.00 | 1.00 | ||||
‡: reference value. *: The choice of variables for the multivariable analysis was based on the results of univariable analysis and clinical correlation. d: HR adjusted by age, serum bilirubin, INR, hepatic encephalopathy, hyponatremia, and kidney dysfunction; e: HR adjusted by age, serum albumin, serum bilirubin; f: HR adjusted by serum albumin, serum bilirubin, INR, serum ammonia; g: HR adjusted by age, serum albumin, serum bilirubin, INR, presence of ascites at baseline. Abbreviations. ESI: erector spine index, HR: hazard ratio, CI: confidence interval, INR: international normalized ratio