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. 2023 Oct 25;24:255. doi: 10.1186/s12931-023-02550-y

Fig. 2.

Fig. 2

mRNA expression of TLR4, MyD88, and pyroptosis pathway molecules in the induced sputum of patients with asthma is upregulated and negatively related to the mRNA expression of MUC1. Induced sputum cells from the HC (n = 12), MMA (n = 34), and SA (n = 18) groups were subjected to RT-qPCR to detect the mRNA expression of TLR4, MyD88, NLRP3, caspase-1, IL-18, and IL-1β. (A-F) mRNA expression of TLR4, MyD88, NLRP3, caspase-1, IL-18, and IL-1β in induced sputum cells. (G-L) Correlation of the mRNA expression of MUC1 with the mRNA expression of TLR4, MyD88, NLRP3, caspase-1, and IL-1β in induced sputum cells of patients with asthma (n = 52). HC = healthy controls (n = 12), MMA = mild-to-moderate asthma (n = 34), SA = severe asthma (n = 18). * p < 0.05; ** p < 0.01; *** p < 0.001; and **** p < 0.0001