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. 2023 Oct 25;24:255. doi: 10.1186/s12931-023-02550-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — TAK-242 partially ameliorates GO-203-exacerbated neutrophilic airway inflammation in OVA/LPS-induced asthmatic mouse. (A, B) HE staining and PAS staining were performed on lung sections in the indicated groups. Images were taken under a microscope at 200× magnification. Scale bar: 50 μm. (C, D) Inflammatory infiltration and hyperplasia of goblet cells were quantified using inflammation and PAS scores. (E) Statistical analysis of the total inflammatory cells, macrophages, neutrophils, eosinophils, and lymphocytes in BALF. (F) The mRNA expression levels of IL-6, IL-8, IL-18, IL-1β, and TNF-α in lung tissues were detected using RT-qPCR. LDH = lactate dehydrogenase. Data are expressed as mean ± SD (n = 6 animals per group) and were analyzed using one-way analysis of variance,*p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001