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. 2023 Oct 25;24:255. doi: 10.1186/s12931-023-02550-y

Fig. 8.

Fig. 8

Mechanisms underlying MUC1 regulation of neutrophilic airway inflammation in asthma. MUC1-CT can interact with TLR4 and hinder the interaction between TLR4 and MyD88, thereby reducing the phosphorylation and nuclear translocation of NF-κB and reducing NLRP3 inflammasome-mediated pyroptosis and neutrophilic airway inflammation. Therefore, MUC1 downregulation in the airways of patients with asthma may be a mechanism of neutrophilic airway inflammation