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. 2023 Oct 26;25:212. doi: 10.1186/s13075-023-03190-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Inhibition of ferroptosis driver ACSL4 attenuates SSc fibrosis. A Schematic illustration of the treatment schedule. B Representative images of immunohistochemistry staining for ACSL4 of murine lung tissue (× 200, × 800). C, D Western blots of ACSL4 expression level in murine lung tissue. E Relative mRNA expression level of ACSL4 by quantitative PCR (n = 6). F Representative photos of the local injected murine skin of each group. G H&E and Masson’s staining representative images of murine skin and lung tissue, data are summarized in graphs (× 200), (n = 8). H HYP content of skin and lung tissue (n = 6). I Relative mRNA levels of fibrosis markers in each group by quantitative PCR (n = 6). (Data are presented as Mean ± SD *p < 0.05, **p < 0.01, ***p < 0.001, * stands for control versus BLM group; #p < 0.05, ##p < 0.01, ###p < 0.001, #stands for BLM group versus BLM + ROSI-treated group)