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. 2023 Oct 26;25:212. doi: 10.1186/s13075-023-03190-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Calpain inhibition halts Calpain-ACSL4 crosstalk and progressive fibrosis. A Schematic illustration of the treatment schedule. B, C Western blots of calpain 1 and calpain 2 in murine skin tissue from each group. D Calpain activity in murine skin tissue from each group. E H&E and Masson’s staining representative images of murine skin and lung tissue, data are summarized in graphs (n = 8). F, G Western blots of fibrosis markers in murine skin tissue from each group. H Relative mRNA levels of ACSL4 from each group. I, J Relative mRNA levels of M1 and M2 markers from each group. (Data are presented as Mean ± SD *p < 0.05, **p < 0.01, ***p < 0.001, * stands for control versus BLM group; #p < 0.05, ##p < 0.01, ###p < 0.001, #stands for BLM group versus BLM + PD150606-treated group)