Table 2.
Hazard ratios (HR) with 95% confidence intervals (CI) for mortality by categories of appetite, fatigue, and albumin in all participants. Appetite and Fatigue was assessed with Edmonton Symptom Assessment System (ESAS), with scores 0–10
| No of subjects | No of events | Total survival time (person-years) | Crude | Multivariable adjusteda | |||
|---|---|---|---|---|---|---|---|
| HR | (95% CI) | HR | (95% CI) | ||||
| Appetite score | |||||||
| Good (0–3) | 287 | 237 | 111.4 | 1.00 | (reference) | 1.00 | (reference) |
| Moderate (4–6) | 146 | 134 | 38.5 | 1.54 | (1.24 to 1.90) | 1.44 | (1.16 to 1.79) |
| Poor (7–10) | 97 | 92 | 21.1 | 1.91 | (1.50 to 2.43) | 1.78 | (1.39 to 2.29) |
| Fatigue score | |||||||
| No/little (0–3) | 240 | 194 | 100.4 | 1.00 | (reference) | 1.00 | (reference) |
| Moderate (4–6) | 183 | 167 | 47.3 | 1.72 | (1.40 to 2.12) | 1.69 | (1.36 to 2.08) |
| Severe (7–10) | 107 | 102 | 23.4 | 2.10 | (1.65 to 2.67) | 1.83 | (1.45 to 2.36) |
| Albumin | |||||||
| ≥ = 36 | 81 | 58 | 40.2 | 1.00 | (reference) | 1.00 | (reference) |
| 26–35 | 370 | 328 | 121.6 | 1.81 | (0.37 to 2.40) | 1.89 | (1.42 to 2.51) |
| < = 25 | 79 | 77 | 9.7 | 5.48 | (3.87 to 7.76) | 5.35 | (3.75 to 7.63) |
| CRP/albumin | |||||||
| Tertile 1(0.02–0.17) | 181 | 146 | 79.9 | 1.00 | (reference) | 1.00 | (reference) |
| Tertile 2(0.17–0.78) | 173 | 147 | 59.7 | 1.30 | (1.03 to 1.63) | 1.39 | (1.10 to 1.75) |
| Tertile 3(0.78–8.63) | 176 | 170 | 31.4 | 2.63 | (2.10 to 3.30) | 2.66 | (2.12 to 3.35) |
aAdjusted for age, sex, cancer diagnosis, cancer treatment, socioeconomic status, and randomization arm