Table 2.
Direct comparison and homogeneity test among interventions
| Intervertion | Virological response (EOF) | Virological response (FU24W) | Biochemical response (EOF) | Biochemical response (FU24W) | Histological response | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR | (95% CI) | HM | RR | (95% CI) | HM | RR | (95% CI) | HM | RR | (95% CI) | HM | RR | (95% CI) | HM | ||||||||
| I2 (%) | p-value | I2 (%) | p-value | I2 (%) | p-value | I2 (%) | p-value | I2 (%) | p-value | |||||||||||||
| A | vs | B | 0.37 | (0.09, 1.56) | - | - | 0.27 | (0.04, 2.07) | - | - | 1.48 | (0.66, 3.33) | - | - | 0.71 | (0.20, 2.53) | - | - | 1.00 | (0.38, 2.61) | - | - |
| A | vs | C | 0.26 | (0.07, 0.98) | - | - | 0.30 | (0.04, 2.12) | - | - | 1.69 | (0.90, 3.17) | - | - | 0.65 | (0.22, 1.95) | - | - | 1.55 | (0.48, 4.93) | - | - |
| A | vs | D | 1.00 | (0.16, 6.3) | - | - | 2.20 | (0.10, 49.06) | - | - | 2.01 | (0.76, 5.35) | - | - | 2.06 | (0.25, 17.34) | - | - | 3.75 | (0.25, 57.45) | - | - |
| B | vs | C | 0.71 | (0.37, 1.36) | - | - | 1.11 | (0.46, 2.71) | - | - | 1.14 | (0.51, 2.56) | - | - | 0.91 | (0.39, 2.14) | - | - | 1.55 | (0.56, 4.29) | - | - |
| B | vs | D | 2.71 | (0.64, 11.4) | - | - | 6.05 | (0.37, 99.49) | - | - | 1.36 | (0.45, 4.09) | - | - | 2.90 | (0.39, 21.7) | - | - | 3.70 | (0.25, 54.07) | - | - |
| B | vs | F | 10.88 | (1.57, 75.48) | - | - | 3.89 | (0.23, 66.95) | - | - | 4.62 | (1.18, 18.05) | - | - | - | - | - | - | 1.04 | (0.15, 7.10) | - | - |
| C | vs | D | 3.84 | (1.02, 14.41) | - | - | 5.30 | (0.34, 82.77) | - | - | 1.19 | (0.45, 3.15) | - | - | 3.17 | (0.47, 21.43) | - | - | 2.50 | (0.16, 39.05) | - | - |
| D | vs | E | 0.93 | (0.67, 1.28) | 0.00 | 0.83 | 0.99 | (0.70, 1.39) | 0.00 | 0.96 | 0.95 | (0.70, 1.29) | 0.00 | 0.94 | 0.93 | (0.67, 1.28) | 0.00 | 0.57 | 0.88 | (0.56, 1.37) | 0.00 | 0.95 |
| D | vs | F | 7.28 | (1.47, 35.99) | 0.21 | 0.26 | 12.25 | (2.39, 62.81) | 0.33 | 0.22 | 2.99 | (1.14, 7.88) | 0.00 | 0.76 | 2.64 | (1.14, 6.12) | 0.00 | 0.42 | 1.05 | (0.36, 3.07) | 0.00 | 0.77 |
| D | vs | G | 2.55 | (1.38, 4.73) | 0.21 | 0.28 | 1.93 | (0.61, 6.17) | 0.00 | 0.38 | 6.09 | (1.92, 19.33) | 0.00 | 0.94 | 5.73 | (0.90, 36.5) | 0.00 | 0.75 | 1.39 | (0.77, 2.52) | 0.00 | 0.97 |
| E | vs | F | 6.11 | (1.45, 25.7) | 0.01 | 0.32 | 1.93 | (0.61, 6.17) | 0.00 | 0.38 | 3.14 | (1.27, 7.8) | 0.00 | 0.67 | 1.87 | (0.79, 4.46) | 0.35 | 0.22 | 1.65 | (0.86, 3.16) | 0.00 | 0.64 |
A: Bulevirtide, B: Bulevirtide + NAs, C: Bulevirtide + IFNα, D: IFNα, E: IFNα + NAs, F: NAs, G: No treatment
HM Heterogeneity measures